Chinese Journal of Organic Chemistry >
New Progress of Fully Continuous Flow Reaction Technologies in Pharmaceutical Synthesis (2019~2022)
Received date: 2023-07-09
Revised date: 2023-09-16
Online published: 2023-09-28
Supported by
National Natural Science Foundation of China(22377097); National Natural Science Foundation of China(21877087); Natural Science Foundation of Hubei Province(2021CFB556); Natural Science Foundation of Hubei Province(2022CFB156); Key Laboratory for Green Chemical Process of Ministry of Education Open Fund(GCP20200201); Hubei Key Laboratory of Novel Reactor and Green Chemical Technology (Wuhan Institute of Technology) Open Fund(40201002)
Continuous flow chemistry is an emerging technology in the chemical pharmaceutical industry. Compared with the traditional batch kettle reaction, continuous flow reaction has the advantages of rapid mass and heat transfer, improves the controllability and safety of the reaction process, and can also integrate the online analysis and purification steps into the flexible operation sequence. The new progress of continuous flow reaction technology in the continuous synthesis process from starting raw material to final active pharmaceutical ingredient (API) from 2019 to 2022 is introduced. Starting from the flow chart of continuous flow reaction, the preparation process and technical advantages of continuous flow reaction are described. At the same time, it is pointed out that the fully continuous flow reaction technology still has some challenges in the process connection and coupling treatment of each single step synthesis transformation, which needs to be further improved.
Key words： flow chemistry; pharmaceuticals; fully continuous flow; synthetic process
Kangbo Feng , Jiong Chen , Shuangxi Gu , Haifeng Wang , Fen'er Chen . New Progress of Fully Continuous Flow Reaction Technologies in Pharmaceutical Synthesis (2019~2022)[J]. Chinese Journal of Organic Chemistry, 2024 , 44(2) : 378 -397 . DOI: 10.6023/cjoc202307005
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