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Chinese Journal of Organic Chemistry >

2024 , Vol. 44 >Issue 2: 550 - 560

DOI: https://doi.org/10.6023/cjoc202310004

ARTICLES

Amide Hydrolysis Reaction Using tert-Butyl Nitrite

  • Suyan Tao ,
  • Zixin Xiang ,
  • Junjie Bai ,
  • Xiao Wan ,
  • Xiaobing Wan
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  • Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, Jiangsu 215123
* Corresponding author. E-mail:

Received date: 2023-10-07

  Revised date: 2023-11-02

  Online published: 2023-11-08

Supported by

National Natural Science Foundation of China(21973068); National Natural Science Foundation of China(21971175)

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Abstract

Amide is a compound that serves important functions and acts as versatile synthons, finding wide applications in organic synthesis and pharmaceutical chemistry. In this study, the mild hydrolysis reaction of primary amides using tert-butyl nitrite is showed, which leads to the formation of diverse carboxylic acids. This method stands out because it operates under neutral conditions, has a wide range of applicable substrates, and is compatible with various functional groups.

Key words： amide; carboxylic acids; tert-butyl nitrite; hydrolysis reaction

Cite this article

Suyan Tao , Zixin Xiang , Junjie Bai , Xiao Wan , Xiaobing Wan . Amide Hydrolysis Reaction Using tert-Butyl Nitrite[J]. Chinese Journal of Organic Chemistry, 2024 , 44(2) : 550 -560 . DOI: 10.6023/cjoc202310004

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