Chinese Journal of Organic Chemistry >
Research Progress in the Synthesis of Azaindoline and Its Derivatives
Received date: 2023-09-08
Revised date: 2023-11-22
Online published: 2023-12-08
Supported by
National Natural Science Foundation of China(22201145); Program of High-Level Talents of Nantong University(03083031); Science and Technology Project of Nantong City(JC12022052)
The azaindoline skeleton exists in a wide range of bioactive molecules and natural products, and has significant biological and pharmaceutical activities. The synthesis of these compounds has attracted great attention from chemists. However, due to the electron-deficient nature of the pyridine ring where the nitrogen atom is located, many traditional methods for the synthesis of indoline cannot effectively construct the azaindoline skeleton. In recent years, chemists have been exploring the synthesis of azaindoline skeleton and have made some progress. According to the different reaction types, the synthesis of azaindolines in recent years and the key reaction mechanisms are reviewed and discussed, and the future development prospect of this research field is prospected.
Key words： azaindoline; synthesis; catalytic reaction
Hao Ye , Haibin Zhang , Ya'nan Wu , Xinxing Wu . Research Progress in the Synthesis of Azaindoline and Its Derivatives[J]. Chinese Journal of Organic Chemistry, 2024 , 44(4) : 1106 -1123 . DOI: 10.6023/cjoc202308025
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