Chinese Journal of Organic Chemistry >
Studies on the Chemical Constituents from the Seeds of Noni and Their Anti-inflammatory Bioactivity
Received date: 2023-09-11
Revised date: 2023-11-16
Online published: 2023-12-08
Supported by
National Natural Science Foundation of China(22367008); National Natural Science Foundation of China(21662012); Innovation Platform for Academicians of Hainan Province(YSPTZX202030); Central Government Guides Local Science and Technology Development(ZY2022HN08); Hainan Normal University “Innovative Entrepreneurship Training Program for College Students”(HSCX2023-17)
A new sesquineolignan moricitan A (1), a new natural product 4-methoxy isoamericanin A (2), a new anthraquinone 1,3-dihydroxy-2,5-dimethoxy-6-(methoxymethyl)anthracene-9,10-dione (7), and seven known compounds 3~6 and 8~10 were obtained from the seeds of Noni. The structures were elucidated using comprehensive spectroscopic methods, and the absolute configuration of 1 was established based on quantum-chemical electronic circular dichroism calculations. The inhibitory activity of all the compounds on NO production in lipopolysaccharide-induced (LPS) mouse leukemia cells of monocyte macrophage (RAW 264.7) cells was evaluated. Compound 1 and 9'-ethyl americanol A (3) exhibited stronger anti-inflam- matory activity in vitro with IC50 values of (2.52±0.22) and (5.46±0.89) μmol/L to that of dexamethasone [IC50=(65.39±1.02) μmol/L], respectively.
Key words： Morinda citrifolia; Noni; lignan; anthraquinone; anti-inflammatory
Qinzhi Wei , Zhangxin Yu , Meng Xu , Wei Xu , Fuling Cen , Yaqi Zhang , Xiaobao Li , Guangying Chen . Studies on the Chemical Constituents from the Seeds of Noni and Their Anti-inflammatory Bioactivity[J]. Chinese Journal of Organic Chemistry, 2024 , 44(4) : 1357 -1362 . DOI: 10.6023/cjoc202309010
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