Chinese Journal of Organic Chemistry >
A New Fatty Acid Glycoside Compound in Munronia Pinnata
Received date: 2023-10-22
Revised date: 2023-11-28
Online published: 2023-12-18
Supported by
Natural Science Foundation of Guangxi(2020GXNSFBA297055); Guangxi Science and Technology Base and Talent Project (Guike AA21196009); National Key Research and Development Program(2022YFD1600302); National Natural Science Foundation of China(U20A2004); Basic Research Fund of Guangxi Academy of Sciences(CQZ-C-1901); Guilin Innovation Platform and Talent Plan(20210102-3); Key Area Research and Development Program of Guangdong Province(2020B1111110003)
The chemical constituents of the aerial parts of Munronia pinnata W. Theobald were investigated by using chro- matographic techniques. Ten compounds were isolated from the 95% ethanol extract of Munronia pinnata. Their structures were identified as munrofatty A (1), 2-[[6-O-((2E)-6R-hydroxy-2,6-dimethyl-2,7-octadienoyl)-β-D-glucopyranosyl]oxy]-2- methylpropanoic acid (2), kaempferol-3-O-(6-O-trans-p-coumaroyl)-β-D-glucopyranoside (3), castanoside A (4), kaempferol- 3-O-(6''-O-cis-pcoumaroyl)-β-D-glucopyranoside (5), aurantiamide acetate (6), blumenol A (7), grasshopper ketone (8), curcusinol (9) and loliolide (10) through detailed analyses of various technical means, including MS, IR, 1D- and 2D-NMR spectroscopic methods, quantum calculation methods and other technical means. Compound 1 is a new compound, while NMR data of compound 2 are presented for the first time. Compound 1 was evaluated for cytotoxicity against HCT116, A549, HepG2, MCF7 and MDAMB cells, and was non-toxic to the tested cells at a concentration of 160 μmol/L.
Key words： meliaceae; Munronia pinnata; munrofatty A; structural identification
Peiyuan Liu , Yulu Wei , Jingru Song , Xiaojie Yan , Fenglai Lu , Yueyuan Cheng , Xuerong Yang , Dianpeng Li . A New Fatty Acid Glycoside Compound in Munronia Pinnata[J]. Chinese Journal of Organic Chemistry, 2024 , 44(4) : 1348 -1356 . DOI: 10.6023/cjoc202310019
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