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Chinese Journal of Organic Chemistry >

2024 , Vol. 44 >Issue 6: 1998 - 2005

DOI: https://doi.org/10.6023/cjoc202312008

ARTICLES

Direct Sulfonylation of Pyrazolones with Sulfonyl Chlorides to Synthesize Pyrazolyl Sulfonates

  • Bin Wang ,
  • Wancang Han ,
  • Linlin Dai ,
  • Yonghong Zhang ,
  • Yu Xia ,
  • Weiwei Jin ,
  • Chenjiang Liu
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  • a Analysis and Testing Center, Xinjiang University, Urumqi 830017
    b Urumqi Key Laboratory of Green Catalysis and Synthesis Technology, Key Laboratory of Oil and Gas Fine Chemicals of Ministry of Education & Xinjiang Uygur Autonomous Region, State Key Laboratory of Chemistry and Utilization of Carbon-Based Energy Resources, College of Chemistry, Xinjiang University, Urumqi 830017
    c College of Future Technology, Xinjiang University, Urumqi 830017
* E-mail: ;

Received date: 2023-12-08

  Revised date: 2024-01-21

  Online published: 2024-02-20

Supported by

National Natural Science Foundation of China(21762041); National Natural Science Foundation of China(21861036); National Natural Science Foundation of China(21961037); Natural Science Foundation of Xinjiang Uyghur Autonomous Region(2022E01042); Natural Science Foundation of Xinjiang Uyghur Autonomous Region(2022TSYCCX0024); Natural Science Foundation of Xinjiang Uyghur Autonomous Region(2021D01E10)

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Abstract

Pyrazole as a core framework exists in many bioactive molecules and has a wide range of applications in pharmaceuticals, agricultural chemicals and other functional materials. Sulfonates are important intermediates in organic synthesis and play a very important role in organic chemistry. A green and efficient method for the synthesis of pyrazolyl sulfonate compounds by using pyrazolones and sulfonyl chlorides as starting materials was developed. This method features the advantages of simple and easy to operate, without the need for any additives, metal or oxidant. It only requires room temperature and water as the solvent to efficiently synthesize important pyrazolyl sulfonates. The smooth progress of the gram scale reaction and product transformation further proves the practicality of this method.

Key words： pyrazolone; sulfonyl chloride; sulfonylation; pyrazolyl sulfonate

Cite this article

Bin Wang , Wancang Han , Linlin Dai , Yonghong Zhang , Yu Xia , Weiwei Jin , Chenjiang Liu . Direct Sulfonylation of Pyrazolones with Sulfonyl Chlorides to Synthesize Pyrazolyl Sulfonates[J]. Chinese Journal of Organic Chemistry, 2024 , 44(6) : 1998 -2005 . DOI: 10.6023/cjoc202312008

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