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Chinese Journal of Organic Chemistry >

2024 , Vol. 44 >Issue 6: 1978 - 1986

DOI: https://doi.org/10.6023/cjoc202312021

ARTICLES

Heterogeneous Iron-Catalyzed Oxyalkylation of Vinylarenes via C(sp3)—H Activation of Cyclic Ethers

  • Lei Yu ,
  • Kang Sheng ,
  • Ting Li ,
  • Conghui Tang
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  • a College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang, Henan 473061
    b Key Laboratory of Material Chemistry for Energy Conversion and Storage, Ministry of Education, Hubei Key Laboratory of Material Chemistry and Service Failure, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074
* E-mail: ;

Received date: 2023-12-22

  Revised date: 2024-02-01

  Online published: 2024-02-28

Supported by

National Natural Science Foundation of China(22371083); National Natural Science Foundation of China(22001086)

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Abstract

Alkene difunctionalization is an important route to construct new chemical bonds over the olefin double bond, oxyalkylation reaction of olefins will provide C—C bond and C—O bond forming products. The current oxyalkylation methods rely in employing tert-butyl hydroperoxide as the oxidant. Therefore, developing an aerobic oxidation system for this transformation is highly desired. Herein, an unprecedented heterogeneous iron catalyzed oxyalkylation of styrene derivatives under mild conditions was reported, using air as oxidant and oxygen source. Detailed catalyst characterization, substrate scope and mechanistic studies were carried out and a proposed mechanism was given.

Key words： alkene; difunctionalization; C(sp3)—H activation; heterogeneous iron catalysis

Cite this article

Lei Yu , Kang Sheng , Ting Li , Conghui Tang . Heterogeneous Iron-Catalyzed Oxyalkylation of Vinylarenes via C(sp3)—H Activation of Cyclic Ethers[J]. Chinese Journal of Organic Chemistry, 2024 , 44(6) : 1978 -1986 . DOI: 10.6023/cjoc202312021

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