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Chinese Journal of Organic Chemistry >

2024 , Vol. 44 >Issue 6: 1938 - 1948

DOI: https://doi.org/10.6023/cjoc202401001

ARTICLES

Nickel-Catalyzed Reductive anti-Arylative Cyclization of 1,6-Enynes with Aryl Halides

  • Yunxin Xing ,
  • Denghong Yan ,
  • Shun Wen ,
  • Jie Bu ,
  • Kun Shen
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  • School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071
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Received date: 2024-01-01

  Revised date: 2024-02-07

  Online published: 2024-03-05

Supported by

National Natural Science Foundation of China(21901192); National Natural Science Foundation of China(22271225); Natural Science Foundation of Hubei Province(2019CFB12); Natural Science Foundation of Hubei Province(2022CFB221)

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Abstract

A nickel-catalyzed reductive trans-arylative cyclization of 1,6-enynes with aryl halides has been developed. This transformation avoids the use of stoichiometric organometallic reagents and features mild conditions, good functional group tolerance and broad substrate scope. This method serves as an efficient platform for the synthesis of various carbo- and heterocycles, which are abundant in many natural products and biologically active compounds.

Key words： nickel catalysis; reductive cross-coupling; 1,6-enyne; tandem cyclization

Cite this article

Yunxin Xing , Denghong Yan , Shun Wen , Jie Bu , Kun Shen . Nickel-Catalyzed Reductive anti-Arylative Cyclization of 1,6-Enynes with Aryl Halides[J]. Chinese Journal of Organic Chemistry, 2024 , 44(6) : 1938 -1948 . DOI: 10.6023/cjoc202401001

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