Chinese Journal of Organic Chemistry >
Synthesis of Benzochromenes via Brønsted Acid Catalyzed Annulation of Naphthol with Propargyl Alcohols
Received date: 2023-12-13
Revised date: 2024-02-23
Online published: 2024-03-13
Supported by
National Natural Sciences Foundation of China(21572126); National Natural Sciences Foundation of China(21901152); Key Scientific and Technological Project of Henan Province(202102310003); Leading Talent Funding Project of Shangqiu Talent Support Plan in Henan Province(SQRC202212004)
Benzeochromenes, also named as naphthopyrans, are widely found in natural products, bioactive molecules and organic functional materials. A simple and efficient strategy for the synthesis of benzeochromenes with propargyl alcohols and β-naphthols under mild conditions was developed, and a series of benzeochromenes were prepared in excellent yields. This protocol has the advantages of broad scope, functional group diversity and mild conditions with H2O as the only byproduct. Moreover, ease of operation and gram-scale preparation portend the practical application.
Key words： naphthopyran; benzeochromene; propargyl alcohols; 2-naphthol
Pin Zhao , Xuwei Shang , Qingqing Luo , Mengyu Liang , Yuan Fu , Mingliang Zhang , Lantao Liu . Synthesis of Benzochromenes via Brønsted Acid Catalyzed Annulation of Naphthol with Propargyl Alcohols[J]. Chinese Journal of Organic Chemistry, 2024 , 44(6) : 1920 -1928 . DOI: 10.6023/cjoc202312012
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