Chinese Journal of Organic Chemistry >
Palladium-Catalyzed Cyclization of 1,6-Enynes
Received date: 2024-01-26
Revised date: 2024-03-05
Online published: 2024-04-10
Supported by
National Key R&D Program of China(2021YFA1500100); National Natural Science Foundation of China(22171279); National Natural Science Foundation of China(22331012); Youth Innovation Promotion Association of Chinese Academy of Sciences(Y2022074)
Functionalized carbo- and hetero-cyclic compounds are widely found in natural products and other bioactive molecules, which are also important scaffolds with significant synthetic value. The cyclization of 1,n-enynes is one of the most atom-economic and efficient approaches. In particular, the palladium-catalyzed cyclization of 1,6-enynes has been extensively studied and has achieved significant advancements. This review focuses on the cyclization of 1,6-enynes initiated by nucleopalladation of alkynes, including hydropalladation, carbopalladation, halopalladation and oxypalladation. It was classified by the nucleopalladation and the recent developments in palladium-catalyzed 1,6-enyne cyclization over the past two decades are systematically summarized. Special emphasis is placed on the asymmetric reactions, and reaction mechanisms, along with further prospects of this field.
Wenjuan Liu , Pinhong Chen . Palladium-Catalyzed Cyclization of 1,6-Enynes[J]. Chinese Journal of Organic Chemistry, 2024 , 44(7) : 2077 -2091 . DOI: 10.6023/cjoc202401032
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