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Chinese Journal of Organic Chemistry >

2024 , Vol. 44 >Issue 7: 2377 - 2380

DOI: https://doi.org/10.6023/cjoc202401038

Study on Isolation, Identification and Bioactivity of Desferrioxamine E and Its Metal-Complexes from Streptacidiphilus jiangxiensis

  • Jinda Li ,
  • Botao Cheng ,
  • Jiwu Huang ,
  • Wen Liu
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  • a College of Chemistry and Materials Science, Shanghai Normal University, Shanghai 200233
    b State Key Labratory of Chemical Biology, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032
* E-mail: ;

Received date: 2024-01-30

  Revised date: 2024-03-11

  Online published: 2024-04-10

Supported by

National Key Research and Development Program of China(2022YFC2303100); National Natural Science Foundation of China(22193070); National Natural Science Foundation of China(32030002)

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Abstract

Research on the genus Streptacidiphilus was mainly focused on the isolation and identification of new species, with relatively less emphasis on the study of secondary metabolites. A new aluminium-complex alumioxamine (3), and two known compounds desferrioxamine E (1) and ferrioxamine E (2) were isolated from the fermentation broth of Streptacidiphilus jiangxiensis CGMCC 4.1857. Their structures were elucidated by MS, IR, NMR and single crystal X-ray diffraction technologies. Structurally, compound 3 features aluminum(III) as the central atom, which is bonded to six oxygen atoms of the ligand, forming a hexadentate complex. Furthermore, in vitro cytotoxicity assays showed that compound 1 exhibited potential inhibitory activity against four human tumor cell lines (Hela, PANC1, A375 and MHCC-97H) at a concentration of 100 μmol/L with cell viability ranging from 4.8% to 66.4%.

Key words： Streptacidiphilus jiangxiensis; secondary metabolites; complexes; cytotoxic activity; crystal structure

Cite this article

Jinda Li , Botao Cheng , Jiwu Huang , Wen Liu . Study on Isolation, Identification and Bioactivity of Desferrioxamine E and Its Metal-Complexes from Streptacidiphilus jiangxiensis[J]. Chinese Journal of Organic Chemistry, 2024 , 44(7) : 2377 -2380 . DOI: 10.6023/cjoc202401038

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