Chinese Journal of Organic Chemistry >
Design, Synthesis and Herbicidal Activity of Novel Benzothiazole-Pyrimidinediones Compounds
Received date: 2023-11-23
Revised date: 2023-12-25
Online published: 2024-04-25
Supported by
National Key Research and Development Program of China(2022YFD1700302); Key Research and Development Program of Hubei Province(2022BBA0042)
Based on the benzothiazole-pyrimidinedione derivatives discovered in the our previous report, a series of novel pyrimidinedione derivatives with benzothiazole as the scaffold, which have not been reported in the literature, were designed and synthesized by the strategy of replacing sulfur bridge with oxygen bridge. All of the target compounds were evaluated for their herbicidal activity in the greenhouse assay at a dose of 150 g a.i./ha, and the results showed that some compounds exhibited good herbicidal activity against the tested six weeds. In particular, ethyl 2-((6-fluoro-5-(3-methyl-2,6-dioxo-4-(trifluoro- methyl)-3,6-dihydropyrimidin-1(2H)-yl)benzo[d]thiazol-2-yl)oxy)acetate (9ac) showed a broad-spectrum herbicidal activity with more than 85% efficacy against the weeds tested.
Baifeng Zheng , Yang Zuo , Qiong Chen , Qiongyou Wu . Design, Synthesis and Herbicidal Activity of Novel Benzothiazole-Pyrimidinediones Compounds[J]. Chinese Journal of Organic Chemistry, 2024 , 44(7) : 2371 -2376 . DOI: 10.6023/cjoc202311025
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