Chinese Journal of Organic Chemistry >
Recent Advances of the Catalysis Systems in the α-C(sp3)—H Functionalization of Glycine Derivatives
Received date: 2024-03-03
Revised date: 2024-03-29
Online published: 2024-05-11
Supported by
Key Research and Development Program of Hubei Province(2023BCB055); Scientific Research Project of Education Department of Hubei Province(Q20211503)
α-Amino acids are essential components of proteins, which are not only widely used in biologically active compound syntheses, medicinal chemistry, and the materials industry, but also are useful as organic catalysts or ligands for asymmetric synthesis. Glycines are the most fundamental and sole achiral α-amino acids, and are particularly useful building blocks in organic synthesis. Direct α-C(sp3)—H functionalization of glycine derivatives or peptides to construct unnatural α-amino acids or peptides has attracted tremendous attention of many scholars in recent decades. The research progress of the α-C(sp3)—H functionalization of glycine derivatives is reviewed during the past five years. The catalysis systems are systematically discussed, and the challenges and opportunities of this field are included.
Key words： a-amino acids; catalysis systems; C(sp3)—H functionalization; glycine; peptides
Liangming Xuan , Wei Zhao , Rundong Fan , Qiongjiao Yan , Wei Wang , Fen'er Chen . Recent Advances of the Catalysis Systems in the α-C(sp3)—H Functionalization of Glycine Derivatives[J]. Chinese Journal of Organic Chemistry, 2024 , 44(9) : 2700 -2721 . DOI: 10.6023/cjoc202403004
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