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Chinese Journal of Organic Chemistry >

2024 , Vol. 44 >Issue 11: 3345 - 3356

DOI: https://doi.org/10.6023/cjoc202403025

REVIEW

Progresses in the Preparation of Chromone Compounds and Their Applications in Organic Synthesis

  • Zhonghao Li ,
  • Yu Zeng ,
  • Yong Zeng ,
  • Wenjin Xu ,
  • Xiying Cao ,
  • Yuting Guo ,
  • Qing Shen ,
  • Zhaoyang Wang
Expand
  • Key Laboratory of Theoretical Chemistry of Environment, Ministry of Education, GDMPA Key Laboratory for Process Control and Quality Evaluation of Chiral Pharmaceuticals, Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, School of Chemistry, South China Normal University, Guangzhou 510006
*Corresponding authors. E-mail:;

Received date: 2024-03-19

  Revised date: 2024-05-03

  Online published: 2024-05-30

Supported by

Guangdong Basic and Applied Basic Research Foundation(2021A1515012342); Extracurricular Scientific Research Project of South China Normal University(23HXKB06); Extracurricular Scientific Research Project of South China Normal University(23HXKB01)

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Abstract

Chromone is the core backbone of flavonoids and its derivatives have different applications. Meanwhile, the α,β-unsaturated ketone structure contained in chromones enables them to undergo reactions such as substitution, cyclization, and asymmetric addition, which promotes the generation of a variety of functionalized chromone analogues or other backbone molecules. Therefore, in addition to chromone natural products, the preparation of chromones and their use as synthons in organic synthesis applications are also of great interest. The preparation methods of chromones are summarized and the recent applications of important chromone synthons in organic synthesis are reviewed on the basis of reaction types and reaction regions.

Key words： chromones; synthons; functionalization; addition reaction

Cite this article

Zhonghao Li , Yu Zeng , Yong Zeng , Wenjin Xu , Xiying Cao , Yuting Guo , Qing Shen , Zhaoyang Wang . Progresses in the Preparation of Chromone Compounds and Their Applications in Organic Synthesis[J]. Chinese Journal of Organic Chemistry, 2024 , 44(11) : 3345 -3356 . DOI: 10.6023/cjoc202403025

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