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Chinese Journal of Organic Chemistry >

2024 , Vol. 44 >Issue 5: 1558 - 1567

DOI: https://doi.org/10.6023/cjoc202309017

ARTICLES

Synthesis and Anti-porcine Pseudorabies Virus (PRV) Activity of Novel N-Pyridinium Bipyrazole Dimer Derivatives

  • Xuehui Hou ,
  • Chen Yao ,
  • Jinqing Song ,
  • Feifei Yang ,
  • Zhangxu He ,
  • Xiaopei Chen ,
  • Jingyu Zhang
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  • a Faculty of Science, Henan University of Animal Husbandry and Economy, Zhengzhou 450046
    b School of Pharmacy, Henan University of Traditional Chinese Medicine, Zhengzhou 450046
    c College of Veterinary Medicine, Henan Agricultural University Zhengzhou 450046
*E-mail:

Received date: 2023-09-18

  Revised date: 2023-12-15

  Online published: 2024-01-30

Supported by

Natural Science Foundation of Henan Province(202300410264); Key Scientific, Technological Project of Henan Province(232102111051); China Postdoctoral Science Foundation(2022M721060)

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Abstract

The porcine pseudorabies virus (PRV) leading to severe neurological and respiratory damage can infect a wide range of vertebrates and humans, which raises concerns regarding the potential cross-species transmission of PRV. However, there is currently a lack of specific antiviral treatments available for PRV. 25 dimer derivatives containing N-pyridine bipyrazole moiety were designed and synthesized based on the principles of molecular splicing and electron isoarrangement. The inhibitory effect of the target compounds on PRV virus was assessed. Preliminary bioassay revealed that most of the compounds exhibited potent anti-PRV activity at a concentration of 10 μmol/L while demonstrating no or minimal toxicity towards a type of porcine kidney cell (PK-15). These novel N-pyridinium bipyrazole dimer derivatives could be regarded as anti-PRV agents for further optimization and development.

Key words： N-pyridinium bipyrazole; dimer derivative; anti-porcine pseudorabies virus (PRV) activity

Cite this article

Xuehui Hou , Chen Yao , Jinqing Song , Feifei Yang , Zhangxu He , Xiaopei Chen , Jingyu Zhang . Synthesis and Anti-porcine Pseudorabies Virus (PRV) Activity of Novel N-Pyridinium Bipyrazole Dimer Derivatives[J]. Chinese Journal of Organic Chemistry, 2024 , 44(5) : 1558 -1567 . DOI: 10.6023/cjoc202309017

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