Chinese Journal of Organic Chemistry >
Copper-Catalyzed Synthesis of Benzofuropyrimidoisoindole Derivatives
Received date: 2024-04-05
Revised date: 2024-05-14
Online published: 2024-06-13
Supported by
Outstanding Youth Fund of Jiangsu Province(BK20211607); Priority Academic Program Development of Jiangsu Higher Education Institutions.
A copper-catalyzed Sonogashira coupling reaction and 5-exo-dig aminocyclization between 2-(2-bromophenyl)- benzofuro[3,2-d]pyrimidin-4(3H)-ones and terminal alkynes were disclosed. The protocol allowed access to a series of 8-benzylidene benzofuro[3',2':4,5]pyrimido[2,1-a]isoindol-6(8H)-one derivatives with high efficiency, broad substrate scope, and excellent functional group compatibility, which were shown to be of a single (E)-configuration by X-ray diffraction analysis.
Heng He , Lanlan Lü , Jianquan Liu , Xiangshan Wang . Copper-Catalyzed Synthesis of Benzofuropyrimidoisoindole Derivatives[J]. Chinese Journal of Organic Chemistry, 2024 , 44(11) : 3427 -3436 . DOI: 10.6023/cjoc202404005
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