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Chinese Journal of Organic Chemistry >

2024 , Vol. 44 >Issue 12: 3702 - 3712

DOI: https://doi.org/10.6023/cjoc202404015

REVIEW

Advances in Organic Reactions Using Phosphorus Acid as Reducing Agent

  • Jing Xiao ,
  • Yuxiang Xie ,
  • Libiao Han
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  • a Key Laboratory of Theoretical Organic Chemistry and Functional Molecule of Ministry of Education, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, Hunan 411201
    b College of Chemistry & Chemical Engineering, Shaoxing University, Shaoxing, Zhejiang 312000
    c Zhejiang Yangfan New Materials Co. Ltd., Shangyu, Zhejiang 312369
*Corresponding authors. E-mail:;

Received date: 2024-04-10

  Revised date: 2024-05-10

  Online published: 2024-06-24

Supported by

National Natural Science Foundation of China(22378107); Natural Science Foundation of Hunan Province(2024JJ5135); Natural Science Foundation of Hunan Province(2022JJ30240)

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Abstract

Organic reduction reactions are one of the most basic chemical reactions, which are widely used in the synthesis of pharmaceuticals, agriculture chemicals, dye industry and fine chemicals. Common reducing agents mainly include hydrogen, metallic compounds (borohydride, lithium aluminum hydride, alkyl aluminium and low-valence metals, etc.), active metals, silane and hydrazine. Phosphorus acid is a common chemical in industry, it is also cheap, easy to access, and easy to use. At present, reactions using phosphorus acid as reducing agents usually do not require transition-metals, and has the advantages of low-cost, simple conditions and simple work-up procedures. However, compared with the extensive application of those common reducing agents in organic reduction reactions, the organic reactions using phosphorus acid as reducing agent are very limited. Organic reduction reactions which are using phosphorus acid as reducing agent are summarized from aspects of reaction type, the scope of substrate and reaction mechanism. Prospects in this field are also discussed.

Key words： phosphorus acid; iodine; reducing agent; reduction reaction; metal-free

Cite this article

Jing Xiao , Yuxiang Xie , Libiao Han . Advances in Organic Reactions Using Phosphorus Acid as Reducing Agent[J]. Chinese Journal of Organic Chemistry, 2024 , 44(12) : 3702 -3712 . DOI: 10.6023/cjoc202404015

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