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Chinese Journal of Organic Chemistry >

2025 , Vol. 45 >Issue 2: 655 - 667

DOI: https://doi.org/10.6023/cjoc202404038

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Progress on Cobalt-Catalyzed C(sp2)—H Activation for the Construction of Nitrogen-Containing Benzo Heterocycles

  • Xun Tian ,
  • Guogang Deng ,
  • Xiaodong Yang
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  • Key Laboratory of Medicinal Chemistry for Natural Resource of Ministry of Education, Yunnan Key Laboratory of Research and Development for Natural Products, School of Pharmacy, Yunnan University, Kunming 650500
*E-mail: ;

Received date: 2024-04-24

  Revised date: 2024-05-27

  Online published: 2024-07-02

Supported by

National Key R&D Program of China(2019YFE0109200); National Natural Science Foundation of China(22361050); Program for Xingdian Talents

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Abstract

Nitrogen-containing benzo heterocycles serve as crucial scaffolds in natural products and biologically active molecules. In recent years, transition metal catalysis has emerged as a powerful strategy in C(sp2)—H activation, making significant contributions to the synthesis of nitrogen-containing benzo heterocycles. Embracing the concept of green and sustainable economy, the abundantly available cobalt metal is gaining attention as an economical catalyst among researchers. In this review, the research progress on cobalt-catalyzed C(sp2)—H activation for the construction of nitrogen-containing benzo heterocycles from 2015 to present is summarized. The cobalt catalysts used can be classified into cyclopentadienyl (Cp)-coordinated CpCo(III) catalysts as well as Cp-free Co(II) catalysts by species, and reaction types can be categorized into intermolecular and intramolecular reactions, which are systematically reviewed according to these classifications. Furthermore, the current limitations and future prospects of this field are summarized and discussed.

Key words： cobalt catalysts; C(sp2)—H activation; cyclization reactions; nitrogen-containing benzo heterocycles; transition metal catalysis

Cite this article

Xun Tian , Guogang Deng , Xiaodong Yang . Progress on Cobalt-Catalyzed C(sp2)—H Activation for the Construction of Nitrogen-Containing Benzo Heterocycles[J]. Chinese Journal of Organic Chemistry, 2025 , 45(2) : 655 -667 . DOI: 10.6023/cjoc202404038

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