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Chinese Journal of Organic Chemistry >

2025 , Vol. 45 >Issue 1: 240 - 245

DOI: https://doi.org/10.6023/cjoc202405007

ARTICLES

Synthesis of Thioureas from Amines and CS2 via Photoredox Catalysis

  • Wei Li ,
  • Yisen Wang ,
  • Rong Zhou ,
  • Wenchao Gao
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  • College of Chemistry and Chemical Engineering, Taiyuan University of Technology, Taiyuan 030024
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Received date: 2024-05-07

  Revised date: 2024-07-02

  Online published: 2024-09-02

Supported by

National Natural Science Foundation of China(21901179)

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Abstract

In recent years, photocatalysis has become an important tool to construct new compounds in synthetic and pharmaceutical chemistry. In this work, various symmetric and unsymmetric thioureas were successfully synthesized by photoredox catalysis using CS2 as thiocarbonyl source. For the mechanism, thiyl radicals were generated via single electron transfer process under photoredox catalysis after the nucleophilic addition of amines to CS2, and then dimerized to reactive disulfides, which reacted with the other amines to form thioureas. The method features mild conditions, good functional group tolerance, and simple operation.

Key words： photochemistry; thioureas; carbon disulfide; green synthesis

Cite this article

Wei Li , Yisen Wang , Rong Zhou , Wenchao Gao . Synthesis of Thioureas from Amines and CS2 via Photoredox Catalysis[J]. Chinese Journal of Organic Chemistry, 2025 , 45(1) : 240 -245 . DOI: 10.6023/cjoc202405007

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