Chinese Journal of Organic Chemistry >
Chiral Ligands for Palladium-Catalyzed Coordination-Assisted Enantioselective C(sp3)—H Functionalization Reactions
Received date: 2024-06-01
Revised date: 2024-07-31
Online published: 2024-09-10
Supported by
National Natural Science Foundation of China(21933007); National Natural Science Foundation of China(21822304)
Abstract Enantioselective C(sp3)—H functionalization reactions have emerged as a powerful and straightforward strategy in the construction of chiral molecules. Palladium, highlighted by its remarkable reactivity, versatility, and functional group tolerance, stands out among transition metal catalysts and is one of the most prevalently employed in enantioselective C(sp3)—H functionalization reactions. In these reactions, chiral ligands play a pivotal role, serving as a decisive factor in controlling both reactivity and stereoselectivity. Focusing on chiral ligands, the latest progress in palladium-catalyzed coordination-assisted enantioselective C(sp3)—H bond functionalization reactions in recent years is summarized, emphasizing the design concept, reaction mechanism, and stereocontrol model of chiral ligands.
Chen-Hui Yuan , Lei Jiao . Chiral Ligands for Palladium-Catalyzed Coordination-Assisted Enantioselective C(sp3)—H Functionalization Reactions[J]. Chinese Journal of Organic Chemistry, 2025 , 45(2) : 602 -619 . DOI: 10.6023/cjoc202406002
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