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Chinese Journal of Organic Chemistry >

2025 , Vol. 45 >Issue 1: 151 - 167

DOI: https://doi.org/10.6023/cjoc202406007

REVIEWS

Research Progress on Transition Metal Catalyzed Hydrocarbonation Reactions of N-Allenamines

  • Junwei Wang ,
  • Hao Xue ,
  • Yingyu Qu ,
  • Ruonan Jiang ,
  • Fachao Yan ,
  • Hui Liu
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  • a School of Chemistry and Chemical Engineering, Shandong University of Technology, Zibo, Shandong 255049
    b Shandong Jincheng Kerui Chemical Co., Ltd., Zibo, Shandong 255035
*E-mail: ;

Received date: 2024-06-07

  Revised date: 2024-08-20

  Online published: 2024-09-19

Supported by

National Natural Science Foundation of China(22078178)

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Abstract

As an electron-rich diene compound, N-allenamines have received wide spread attention in recent years due to its different reaction sites and high reactivity. The dual reactivity of N-allenamines enables functionalization at C(1)-C(3) sites of the nitrogen atom, facilitating region- and stereoselective modifications. The transition metal-catalyzed functionalization of N-allenamines, which selectively yields either proximal or distal adducts, plays a crucial role in the synthesis of complex frameworks in drugs and natural products. The examples in the review are classified based on the type of transition metal used. In addition, this review briefly discusses the reaction mechanism, which is crucial for selective regulation of hydrocarbonnation reactions and the development of new reaction types.

Key words： N-allenamines; hydrocarbonation; functionalization; regioselectivity

Cite this article

Junwei Wang , Hao Xue , Yingyu Qu , Ruonan Jiang , Fachao Yan , Hui Liu . Research Progress on Transition Metal Catalyzed Hydrocarbonation Reactions of N-Allenamines[J]. Chinese Journal of Organic Chemistry, 2025 , 45(1) : 151 -167 . DOI: 10.6023/cjoc202406007

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