Chinese Journal of Organic Chemistry >
Recent Progress in Selective C—H Chlorination
Received date: 2024-06-21
Revised date: 2024-08-26
Online published: 2024-09-27
Supported by
Natural Science Foundation of Henan Province(222300420056); Natural Science Foundation of Henan Province(222300420204)
The importance of organic chlorides in pharmaceutical, material, and synthetic chemistry has made the constru- ction of C—Cl bonds a significant focus in organic chemistry. The cleavage and functionalization of C—H bonds with high atomic efficiency, leading to direct conversion into desired functional groups, is seen as a promising approach for creating new substances. Recent advancements in C—H bond activation/tranformation have led to the development of C—H chlorination reactions as viable alternatives to traditional halogenation methods. This review provides an overview of the progress made in C—H bond chlorination reactions over the last decade.
Key words： chlorination; C—H bonds; selective; umpolung
Juanjuan Wang , Yan Shi , Yingxian Tian , Bingxian Liu . Recent Progress in Selective C—H Chlorination[J]. Chinese Journal of Organic Chemistry, 2025 , 45(2) : 574 -591 . DOI: 10.6023/cjoc202406030
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