Chinese Journal of Organic Chemistry >
Electron Donor-Acceptor (EDA) Complex-Driven Activation of N-α C—H Bonds
Received date: 2024-06-30
Revised date: 2024-08-25
Online published: 2024-09-30
Supported by
National Natural Science Foundation of China(21772195); Fundamental Research Funds for the Central Universities(DUT22QN213)
Electron donor-acceptor (EDA) complexes formed by electron donors and electron acceptors are triggering many amazing photochemical reactions. Under visible light irradiation, the EDA complexes undergo a single electron transfer (SET) process, in which electrons are transferred from the donor to the electron acceptor to create free radical anion-cation pairs and initiate subsequent reactions. This strategy does not require an additional photocatalyst under mild reaction conditions with light as an external energy source, making this system compatible well with most substrates. Amines, such as aza-aromatics and aliphatic amines, have been widely used as electron-rich substrates as electron donors in EDA complexes in recent years. Moreover, the reaction intermediates initiated by these EDA complexes are predictable and site-selective, with unique reactive properties at the N-α position after the formation of EDA complexes, and have been used in the synthesis of complex nitrogen-containing organic molecules. The photochemical reactions of nitrogen-containing aromatics and amines as EDA electron donors for the construction of C—X bonds (X=C, N) at the N-α position are reviewed, and an outlook for the development of this field is provided.
Junfeng Yang , Yanqiu Zhao , Lei Shi . Electron Donor-Acceptor (EDA) Complex-Driven Activation of N-α C—H Bonds[J]. Chinese Journal of Organic Chemistry, 2025 , 45(2) : 559 -573 . DOI: 10.6023/cjoc202406050
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