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Chinese Journal of Organic Chemistry >

2025 , Vol. 45 >Issue 4: 1360 - 1368

DOI: https://doi.org/10.6023/cjoc202406031

ARTICLES

Electrochemically Promoted Transesterification Reaction of Glycine Derivatives

  • Xiaoqin You ,
  • Kejin Huang ,
  • Shiyi Zhuang ,
  • Chenjiang Liu ,
  • Weiwei Jin
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  • a Key Laboratory of Special Agricultural Products Quality and Hazards Controlling Technology of Zhejiang Province, College of Life Sciences, China Jiliang University, Hangzhou 310018
    b College of Chemistry, Xinjiang University, Urumqi 830017
† These authors contributed equally to this work.
* E-mail: ;
;

Received date: 2024-06-21

  Revised date: 2024-09-15

  Online published: 2024-10-11

Supported by

National Natural Science Foundation of China(22161044); Scientific Research Foundation of China Jiliang University(01101-231067)

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Abstract

In an undivided cell, using N-phenylglycine ethyl ester as the model substrate, the reaction conditions were optimized. The results showed that the optimal reaction conditions were at room temperature and air condition, using nickel and graphite plate as anode and cathode materials respectively, 2.0 equiv. of NaBr as the electrolyte, ethylene glycol (EG)/dime- thyl-acetamide (DMA) (V∶V=3∶1) as the mixed solvent, and reacting under 6 mA constant current for 3 h. The transesterification reaction could afford various corresponding glycine derivatives up to 88% yield. This mild reaction condition without adding any transition metal, acid or base, was complied with the concept of green chemistry. In addition, 1.32 g of esterification products was successfully synthesized in a gram scale experiment, which also demonstrated the potential value of electrochemical transesterification of glycine derivatives.

Key words： electrochemistry; glycine derivatives; transesterification

Cite this article

Xiaoqin You , Kejin Huang , Shiyi Zhuang , Chenjiang Liu , Weiwei Jin . Electrochemically Promoted Transesterification Reaction of Glycine Derivatives[J]. Chinese Journal of Organic Chemistry, 2025 , 45(4) : 1360 -1368 . DOI: 10.6023/cjoc202406031

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