Chinese Journal of Organic Chemistry >
Advances in Selective Allylic C—H Amination of Internal Olefins
Received date: 2024-07-03
Revised date: 2024-09-02
Online published: 2024-10-11
Supported by
National Natural Science Foundation of China(22071149)
In recent years, the allylic C—H amination of internal olefins has undergone rapid development. This reaction introduces nitrogen sources into the allylic positions of internal olefins via C—H activation efficiently to form new C—N bonds, thereby synthesizing nitrogen-containing compounds with significant biological activity and pharmaceutical potential. Given the relatively low reactivity of internal olefins and the challenges of chemoselectivity, regioselectivity and stereoselectivity during the reaction, the allylic C—H amination of internal olefins has been a great challenge for organic chemists. This review primarily covers the selective allylic C—H amination of internal olefins in recent years, categorizing the methods based on the mechanism of distinguishing different allylic C—H bonds to achieve selective amination, and summarizes the research progress in this field and its potential applications in synthesizing biologically active molecules.
Key words： internal olefin; allylic; amination
Yuan She , Shuyu Zhang , Le Wang . Advances in Selective Allylic C—H Amination of Internal Olefins[J]. Chinese Journal of Organic Chemistry, 2025 , 45(2) : 531 -545 . DOI: 10.6023/cjoc202407007
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