Chinese Journal of Organic Chemistry >
Recent Advances in the Synthesis of P-Stereogenic Compounds via Desymmetrization Strategy
Received date: 2024-06-20
Revised date: 2024-09-30
Online published: 2024-10-18
Supported by
National Natural Science Foundation of China(21602065); National Natural Science Foundation of China(21931013); Natural Science Foundation of Fujian Province(2022J02009); Open Research Fund of School of Chemistry and Chemical Engineering, Henan Normal University.
Organophosphorus compounds are extensively utilized in the field of medicine, materials, life sciences, and organic synthesis, among which chiral phosphorus compounds are the most widely used. Therefore, the construction of chiral phosphorus centers has always been the hotspot and challenge in organic synthesis. Traditional synthesis methods are mainly focused on chiral resolution and chiral induction strategies. Recently, the construction of chiral phosphorus centers via asymmetric catalysis has been well developed. The recently development of desymmetrization strategies in the construction of phos- phorus centers is summarized, mainly focused on the transformation of C—H, C=C, C≡C bonds and hydroxyl group. What’s more, the deficiencies of current strategies and the trends of future development have also been discussed.
Key words： P-stereogenic center; desymmetrization; C—H bond activation
Guotao Lin , Jian Xu , Qiuling Song . Recent Advances in the Synthesis of P-Stereogenic Compounds via Desymmetrization Strategy[J]. Chinese Journal of Organic Chemistry, 2024 , 44(12) : 3621 -3638 . DOI: 10.6023/cjoc202406029
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