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Chinese Journal of Organic Chemistry >

2025 , Vol. 45 >Issue 2: 516 - 530

DOI: https://doi.org/10.6023/cjoc202406033

REVIEWS

Recent Advances in Transition-Metal Catalyzed C—H Bond Activation for the Synthesis of C(sp3)-Fluoroalkyl Compounds

  • Manman Wang ,
  • Wenhui Xi ,
  • Hao Wu ,
  • Dachang Bai
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  • State Key Laboratory of Antiviral Drugs, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007
*E-mail:

Received date: 2024-06-22

  Revised date: 2024-08-23

  Online published: 2024-10-18

Supported by

National Natural Science Foundation of China(22471063); Natural Science Foundation of Henan Province(242300421351); Natural Science Foundation of Henan Province(222102310562); Henan Provincial Postdoctoral Science Foundation(202103087)

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Abstract

Transition-metal catalyzed insert C—H bond activation has gained great attention for the last decades, which would provide a straightforward and attractive strategy for the synthesis of organofluorine compounds. Compared with aryl and alkynyl fluoroalkyl compounds, the synthesis of C(sp3)-fluoroalkyl compounds through C—H bond activation still lag behind. This review highlights the recent advances in the synthesis of alkyl fluoroalkyl compounds through the transition-metal (Rh, Ru, Pd, Cu, Ir, Ni, Mn, etc.) catalyzed C—H bond activation. The very recently developed chiral fluorinated compound synthesis through asymmetric C—H bond activation is included.

Key words： C—H bond activation; transition-metal catalyst; C(sp3)-fluoroalkyl compounds

Cite this article

Manman Wang , Wenhui Xi , Hao Wu , Dachang Bai . Recent Advances in Transition-Metal Catalyzed C—H Bond Activation for the Synthesis of C(sp3)-Fluoroalkyl Compounds[J]. Chinese Journal of Organic Chemistry, 2025 , 45(2) : 516 -530 . DOI: 10.6023/cjoc202406033

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