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Chinese Journal of Organic Chemistry >

2025 , Vol. 45 >Issue 2: 498 - 515

DOI: https://doi.org/10.6023/cjoc202406042

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Recent Advances in Enantioselective Radical Reactions of C(sp3)—H Bond

  • Tianpeng Ling ,
  • Haitao Qin ,
  • Feng Liu
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  • a Jiangsu Key Laboratory of Neuropsychiatric Diseases and Department of Medicinal Chemistry, College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu 215123
    b Sate Key Laboratory of Fluorine And Nitrogen Chemisty and Advanced Materials, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032
*E-mail: ;

Received date: 2024-06-28

  Revised date: 2024-09-09

  Online published: 2024-10-18

Supported by

National Natural Science Foundation of China(22171200); Priority Academic Program Development of the Jiangsu Higher Education Institutes(PAPD)

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Abstract

The activation of carbon-hydrogen bonds is considered one of the most attractive techniques in synthetic organic chemistry due to its potential to shorten synthetic routes and complement traditional synthetic strategies. In recent years, owing to the significant growth in foundational knowledge and advancements in various technologies, new ideas about asymmetric radical reactions have continuously emerged, leading to numerous novel catalytic methods. The enantioselective radical reactions involving C(sp3)—H bonds published since 2020 are reviewed. The methods of directly or indirectly breaking C—H bonds through various pathways, such as energy transfer, single-electron transfer, and hydrogen atom transfer, to form carbon radicals and subsequently construct chiral C—C, C—N, and C—O bonds, are discussed.

Key words： C—H bond; radical reaction; enantioselectivity

Cite this article

Tianpeng Ling , Haitao Qin , Feng Liu . Recent Advances in Enantioselective Radical Reactions of C(sp3)—H Bond[J]. Chinese Journal of Organic Chemistry, 2025 , 45(2) : 498 -515 . DOI: 10.6023/cjoc202406042

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