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Chinese Journal of Organic Chemistry >

2025 , Vol. 45 >Issue 4: 1411 - 1416

DOI: https://doi.org/10.6023/cjoc202407037

A New Steroid from Armillaria gallica

  • Jingjing Zhang ,
  • Huiqiong Li ,
  • Xingjie Zhang ,
  • Yongpeng Wang ,
  • Xuemei Zhou ,
  • Weilie Xiao ,
  • Lijun Cheng ,
  • Xiaoli Li
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  • a Yunnan Characteristic Plant Extraction Laboratory Co. Ltd., Key Laboratory of Medicinal Chemistry for Natural Resource (Ministry of Education), School of Pharmacy, Yunnan University, Kunming 650500
    b Yunnan Key Laboratory of Gastrodia and Fungi Symbiotic Biology, College of Agriculture and Life Sciences, Zhaotong University, Zhaotong, Yunnan 657000
    c Institute of International Rivers and Eco-Security, Yunnan University, Kunming 650500
    d School of Chemical Science and Technology, Yunnan University, Kunming 650500
    e Southwest United Graduate School, Kunming 650092
† These authors contributed equally to this work.
* E-mail: ;
;

Received date: 2024-07-24

  Revised date: 2024-09-06

  Online published: 2024-10-18

Supported by

National Natural Science Foundation of China(82260682); Yunnan Key Laboratory of Gastrodia and Fungi Symbiotic Biology of Zhaotong University(TMKF2023A01); Yunnan Characteristic Plant Screening and R & D Service CXO Platform(2022YKZY001); Project of Yunling Scholars of Yunnan Province

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Abstract

A chemical investigation on the cultures extract of the basidiomycete Armillaria gallica Marxm. & Romagn. led to the isolation of eight compounds, including a new steroid armillanal D (1), a new natural product VD2-1 (8) and six known compounds. The structure of 1 was elucidated on the basis of extensive 1D and 2D-NMR spectra analysis, HR-ESI-MS, and electronic circular dichroism (ECD) spectra. The inhibitory activity of these compounds except 8 on NLRP3 inflammasome activation in Nigericin-induced mouse macrophage (J774A.1) cells was evaluated. Chaxine C (6) exhibited potential anti- inflammatory activity in vitro with IC50 value of (4.97±0.81) μmol/L.

Key words： Armillaria gallica; fungal metabolite; steroid; anti-inflammatory activity

Cite this article

Jingjing Zhang , Huiqiong Li , Xingjie Zhang , Yongpeng Wang , Xuemei Zhou , Weilie Xiao , Lijun Cheng , Xiaoli Li . A New Steroid from Armillaria gallica[J]. Chinese Journal of Organic Chemistry, 2025 , 45(4) : 1411 -1416 . DOI: 10.6023/cjoc202407037

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