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Chinese Journal of Organic Chemistry >

2025 , Vol. 45 >Issue 4: 1153 - 1165

DOI: https://doi.org/10.6023/cjoc202407032

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Recent Progress in the Synthesis of the Malagasy Alkaloids

  • Weigang He ,
  • Yadong Liu ,
  • Yingkai Deng ,
  • Xianyu Sun
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  • School of Biology and Food Engineering, Changshu Institute of Technology, Changshu, Jiangsu 215500
* E-mail: ;

Received date: 2024-07-18

  Revised date: 2024-09-25

  Online published: 2024-11-08

Supported by

Natural Science Foundation of Jiangsu Province(BK20210939); National Natural Science Foundation of China(22401019)

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Abstract

The Malagasy alkaloids have characteristic trans-fused C/D ring systems and multiple chiral centers, which pose great challenge for their synthesis research. These alkaloids also have potential synergistic anti-malarial activity, especially malagashanine as a natural sensitizer, which can enhance the sensitivity of drug-resistant plasmodium to chloroquine. The unique and challenging structure combined with preonunced pharmacological activity makes the synthesis of these natural products attractive, and their synthesis research also has important value for the development of new antimalarial drugs. The current research progress in the synthesis of the Malagasy alkaloidshis is summarized, including semi-synthesis, core skeleton construction, and total synthesis.

Key words： Malagasy alkaloids; total synthesis; skeleton construction; semi-synthesis; antimalarial activity

Cite this article

Weigang He , Yadong Liu , Yingkai Deng , Xianyu Sun . Recent Progress in the Synthesis of the Malagasy Alkaloids[J]. Chinese Journal of Organic Chemistry, 2025 , 45(4) : 1153 -1165 . DOI: 10.6023/cjoc202407032

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