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Chinese Journal of Organic Chemistry >

2025 , Vol. 45 >Issue 4: 1276 - 1282

DOI: https://doi.org/10.6023/cjoc202411014

ARTICLES

CuI/4-Hydroxy Picolinohydrazide Catalyzed Coupling Reaction of (Hetero)aryl Chlorides with Sodium Aryl Sulfinates

  • Sailuo Li ,
  • Dawei Ma
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  • a School of Physical Science and Technology, ShanghaiTech University, Shanghai 201210
    b State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032
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Received date: 2024-11-14

  Revised date: 2024-11-26

  Online published: 2024-11-28

Supported by

National Natural Science Foundation of China(21991110)

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Abstract

By using a newly developed 4-hydroxy picolinohydrazide as the ligand, Cu-catalyzed coupling of (hetero)aryl chlorides with sodium aryl sulfonates proceeded smoothly at 130 ℃ to give a series of biarylsulfones in 53%~96% yields. This represents the first metal-catalyzed coupling reaction of (hetero)aryl chlorides with sodium aryl sulfonates. Aryl and heteroaryl chlorides bearing either electron-donating or electron-withdrawing groups were applicable for this coupling reaction.

Key words： coupling reaction; copper catalysis; ligand; (hetero)aryl chloride; biarylsulfone

Cite this article

Sailuo Li , Dawei Ma . CuI/4-Hydroxy Picolinohydrazide Catalyzed Coupling Reaction of (Hetero)aryl Chlorides with Sodium Aryl Sulfinates[J]. Chinese Journal of Organic Chemistry, 2025 , 45(4) : 1276 -1282 . DOI: 10.6023/cjoc202411014

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