Chinese Journal of Organic Chemistry >
Photoinduced Difluoromethylation/Cyclization of 2-Aryl Indoles with HCF2SO2Na
Received date: 2024-09-09
Revised date: 2024-11-08
Online published: 2024-12-06
Supported by
Scientific Research Foundation of Hunan Provincial Education Department(23B0650); Key Research Project of Hunan University of Arts and Sciences(24ZZ02)
Difluoromethyl compounds are widely found in natural products, bioactive molecule and pharmaceuticals. A visible-light induced difluoromethylation/cyclization of 2-aryl indoles is described to construct indolo[2,1-a]isoquinolin-6(5H)-one derivatives using the inexpensive and easy-to-handle HCF2SO2Na as an HCF2 sources. Diverse difluoromethylated indolo[2,1-a]isoquinolines were readily obtained in moderate to good yields. Mechanistic studies demonstrate that the reaction may involve a radical process.
Jie Jiang , Jiali Li , Ruohan Pan , Yu Chen , Jiale Liu , Yucai Tang . Photoinduced Difluoromethylation/Cyclization of 2-Aryl Indoles with HCF2SO2Na[J]. Chinese Journal of Organic Chemistry, 2025 , 45(4) : 1239 -1248 . DOI: 10.6023/cjoc202409008
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