Chinese Journal of Organic Chemistry >
Application of Acyl Radical in Total Synthesis of Natural Products
Received date: 2024-09-24
Revised date: 2024-11-28
Online published: 2024-12-20
Supported by
National Natural Science Foundation of China(21925106); National Natural Science Foundation of China(21921002)
Acyl radicals have received extensive attention from organic synthetic chemists due to their unique structural features and high reactivity. In recent years, with the continuous innovation of their acyl sources and initiation modes, acyl radicals have been widely used in various chemical transformations. Especially in the critical step of the late stage of natural product synthesis, acyl radicals have become one of the effective and important strategies compatible with a wide range of functional groups due to the advantages of their smaller site resistance and less susceptibility to metal-mediated β-elimination reactions. Application of acyl radicals as a key step in the synthesis of natural products is summarized.
Key words： acyl radicals; natural products; total synthesis; radical cyclization
Ying Xie , Shaomin Fu , Bo Liu . Application of Acyl Radical in Total Synthesis of Natural Products[J]. Chinese Journal of Organic Chemistry, 2025 , 45(3) : 852 -861 . DOI: 10.6023/cjoc202409033
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