Chinese Journal of Organic Chemistry >
Recent Advance in the Synthesis of Tricyclic Marine Alkaloids: Cylindricines, Lepadiformines, and Fasicularin
Received date: 2024-10-12
Revised date: 2024-12-01
Online published: 2024-12-20
Supported by
National Natural Science Foundation of China(22271172); National Natural Science Foundation of China(22471139)
Cylindricines, lepadiformines and fasicularin consititute a small class of tricyclic marine alkaloids featuring a perhydropyrrolo[2,1-j]quinolines (6/6/5) or perhydropyrido[2,1-j]quinolines (6/6/6) core skeleton. These natural products possess novel chemical structures and exhibit a wide range of biological activities, thus attracting significant interest from synthetic chemists over the past four decades. The recent advance in the synthesis of this unique class of natural products since 2017 is summarized, focusing on the key steps that enable the assembly of their tricyclic skeletons.
Key words： alkaloid; marine natural product; total synthesis
Yunshan Li , Yuxin Zhang , Yefeng Tang . Recent Advance in the Synthesis of Tricyclic Marine Alkaloids: Cylindricines, Lepadiformines, and Fasicularin[J]. Chinese Journal of Organic Chemistry, 2025 , 45(3) : 837 -851 . DOI: 10.6023/cjoc202410006
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