Chinese Journal of Organic Chemistry >
Application of Planar Chiral Cyclopentadienyl Rhodium Catalysts without Chiral Substituents in Asymmetric C—H Activation
Received date: 2024-10-05
Revised date: 2024-11-24
Online published: 2024-12-27
Supported by
National Key R&D Program of China(2022YFA1504303); Guangdong Basic Research Center of Excellence for Functional Molecular Engineering.
Owing to the high stability, adjustability, and unique reactivity of chiral cyclopentadienyl rhodium (CpRh) catalysts, they are widely used in asymmetric C—H activation reactions for rapid construction of diverse and complex molecules bearing central chirality, planar chirality, axial chirality and helical chirality. According to whether the Cp ligand in chiral CpRh catalysts is chiral, the catalysts can be divided into chiral Cp-derived catalysts and prochiral Cp-derived catalysts. Currently, the development of the former has achieved great success, while research on the latter is relatively limited. The syntheses of planar chiral cyclopentadienyl rhodium catalysts without chiral substituents and their application in asymmetric C—H activation are summarized. The stereocontrol model and the mechanism are also discussed. Finally, the opportunities and challenges in developing the planar chiral cyclopentadienyl rhodium catalysts without chiral substituents are discussed.
Key words： cyclopentadienyl; rhodium; planar chirality; asymmetric catalysis; C—H activation
Yu Zou , Weicong Guo , Jun Wang . Application of Planar Chiral Cyclopentadienyl Rhodium Catalysts without Chiral Substituents in Asymmetric C—H Activation[J]. Chinese Journal of Organic Chemistry, 2025 , 45(2) : 466 -476 . DOI: 10.6023/cjoc202410002
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