Since N-trifluoromethylamide compounds contain both amide and N-CF₃ functional groups, which are of significant importance in physical and life science, N-trifluoromethylamides have become increasingly popular among pharmacists, materials chemists, and organic synthetic chemists in recent years. However, the development of new methods for efficient synthesis of N-trifluoromethylamides from abundant and readily available substrates remains a challenging scientific problem. Over the past 70 years, synthetic methodologies for these compounds have developed rapidly, utilizing four strategies: electrochemical oxidative fluorination, synthesis using the key synthetic building block (N-trifluoromethyl)difluoro-imide, synthesis using the building blocks isothiocyanates and oxidation coupling. This review focuses on the synthesis of N-trifluoromethylamides, summarizes the synthesis strategies of this kind of compounds, outlines the development status of synthesis methods in recent years, sorts out and compares various synthesis strategies, and anticipates the potential development direction for N-trifluoromethylamides synthesis methods in the future.