Chinese Journal of Organic Chemistry >
Progress on the Total Synthesis of Ryania Diterpenoids
Received date: 2024-09-26
Revised date: 2024-12-19
Online published: 2025-01-03
Supported by
National Natural Science Foundation of China(22371176); National Natural Science Foundation of China(22201168)
Ryania diterpene natural products were isolated from Ryania speciosa in the Central/South American, structurally which have a cage-type pentacyclic core, multiple continuous stereocenters, and a high oxidation state. Biological studies have found that its member ryanodine has a specific regulatory effect on myocardial calcium ion channels (PyR). It is one of the few organic small molecule compounds with this function discovered so far and has potential medicinal value for treating cardiovascular diseases. However, the complex chemical structure makes the synthesis of these natural products full of challenges. Herein the current research progress of organic chemists on the total synthesis of these natural products is reviewed.
Key words： ryania diterpenoid; natural product; total synthesis
Long Meng , Jin-Bao Qiao , Yu-Ming Zhao . Progress on the Total Synthesis of Ryania Diterpenoids[J]. Chinese Journal of Organic Chemistry, 2025 , 45(3) : 804 -813 . DOI: 10.6023/cjoc202409037
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