ARTICLE

Brønsted Acid Catalyzed Conjugate Addition of Thiocarboxylic Acids to In Situ-Generated (aza-)ortho-Quinone Methides

  • Xue Xiu ,
  • Yang Huier ,
  • Huang Zeshen ,
  • Lang Ming ,
  • Liu Wenfeng
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  • Wuyi University, School of Pharmacy and Food Engineering, Jiangmen, 529020

Received date: 2025-01-23

  Revised date: 2025-02-21

  Online published: 2025-03-13

Supported by

High-Level Talent Research Start-up Project of Wuyi University (No. 2019AL025), the Jiangmen City Science and Technology Basic Research Project (No. 2022JC01013).

Abstract

An efficient Brønsted acid catalyzed conjugate addition of thiocarboxylic acids to in situ-generated ortho-quinone methides (o-QMs) and aza-ortho-quinone methides (aza-o-QMs) has been reported. The reaction has the advantages of broad substrate scope, mild reaction conditions, easy operation and excellent yield. This study provides a new synthetic methodology for the efficient construction of structurally diverse thioesters under mild conditions.

Cite this article

Xue Xiu , Yang Huier , Huang Zeshen , Lang Ming , Liu Wenfeng . Brønsted Acid Catalyzed Conjugate Addition of Thiocarboxylic Acids to In Situ-Generated (aza-)ortho-Quinone Methides[J]. Chinese Journal of Organic Chemistry, 0 : 202411004 -202411004 . DOI: 10.6023/cjoc202411004

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