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DOI: https://doi.org/10.6023/cjoc202507011

ARTILCE

Silver-catalyzed tandem decarboxylative cyclization of 2,2-difluoro-2-(phenylthio)acetic acids with 2-aryl-N-acrylamide indoles

  • Jiale Liu ,
  • Yucai Tang ,
  • Qiumei Yin ,
  • Jiaming Huang ,
  • Shiqiang Deng ,
  • Weiming Xia ,
  • Jie Jiang ,
  • Zu-Li Wang
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  • aCollege of Chemistry and Materials Engineering, Hunan Province Engineering Research Center of Electroplating Wastewater Reuse Technology, Hunan University of Arts and Science, Changde 415000
    bSchool of Chemical Engineering, Nanjing Forestry University, Nanjing 210037

Received date: 2025-07-09

  Revised date: 2025-08-24

  Online published: 2025-09-18

Supported by

Scientific Research Foundation of Hunan Provincial Education Department (23B0650), the Key Research Project of Hunan University of Arts and Sciences (No.24ZZ02) and the Technology Innovation and Development Guidance Program of Chang De (2025ZD124).

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Abstract

The introduction of -SCF2- motif into organic molecules would increases the bioactivity significantly. We herein describe a silver-catalyzed tandem decarboxylative cyclization of 2,2-difluoro-2-(phenylthio)acetic acids with 2-aryl-N-acrylamide indoles, furnishing 28 examples of SCF2-substituted indolo[2,1-a]isoquinoline derivatives in moderate to good yields. Mechanistic studies revealed that a radical pathway is proposed in this transformation.

Key words： silver; decarboxylation; thiodifluoromethylation; indolo[2,1-a]isoquinoline derivatives

Cite this article

Jiale Liu , Yucai Tang , Qiumei Yin , Jiaming Huang , Shiqiang Deng , Weiming Xia , Jie Jiang , Zu-Li Wang . Silver-catalyzed tandem decarboxylative cyclization of 2,2-difluoro-2-(phenylthio)acetic acids with 2-aryl-N-acrylamide indoles[J]. Chinese Journal of Organic Chemistry, 0 : 0 . DOI: 10.6023/cjoc202507011

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