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Chinese Journal of Organic Chemistry >

0 202506033 - 202506033

DOI: https://doi.org/10.6023/cjoc202506033

REVIEW

Recent Advances of C-H Phosphonylation of (Hetero) arenes under Electrochemical Conditions

  • Liu Ruoyu ,
  • Liang Bingyu ,
  • Chen Shuyang ,
  • Sun Hongxian ,
  • Sun Yibing ,
  • Ye Yong
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  • aNanyang Normal University, Henan Nanyang 473000;
    bHenan Academy of Sciences, Quality Inspection and Analysis Research Center;
    cZhengzhou University, Henan Zhengzhou 450000

Received date: 2025-06-26

  Revised date: 2025-08-08

  Online published: 2025-10-10

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Abstract

Phosphonylated (hetero)arenes, as an important class of organophosphorus compounds, exhibit broad application value in fields such as organic catalysis, medicinal chemistry, and materials science. Among various synthetic approaches, the C-H phosphonylation of (hetero)arenes stands out as one of the most efficient strategies for synthesizing these compounds due to its atom economy and step simplicity. In recent years, with the rapid development of organic electrochemistry, significant breakthroughs have been achieved in electrochemically driven C-H phosphonylation. Compared with traditional methods, the electrochemical strategy offers distinct advantages: (1) it replaces chemical oxidants with electrons, improving atom economy; and (2) it demonstrates excellent functional group compatibility under mild conditions. This review summarizes the latest advances in the electrochemical C-H phosphonylation of (hetero)arenes, with a focus on reaction mechanisms and substrate scope. For clarity, the discussed reaction systems are categorized into two major classes based on the electrolysis mode (direct electrolysis vs. indirect electrolysis).

Key words： organic electrosynthesis; electrooxidation; electrocatalysis; phosphonylation; (hetero)arenes

Cite this article

Liu Ruoyu , Liang Bingyu , Chen Shuyang , Sun Hongxian , Sun Yibing , Ye Yong . Recent Advances of C-H Phosphonylation of (Hetero) arenes under Electrochemical Conditions[J]. Chinese Journal of Organic Chemistry, 0 : 202506033 -202506033 . DOI: 10.6023/cjoc202506033

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