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Chinese Journal of Organic Chemistry >

0 260514

DOI: https://doi.org/10.6023/cjoc202512002

ARTICLE

Photoinduced C-F Bond Cleavage α-Trifluoromethyl Alkenes for the Synthesis of gem-Difluoroalkenes

  • Wang Bin ,
  • Ye Bo ,
  • Wang Lei ,
  • He Hong ,
  • Ma Yongmin
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  • aAdvanced Research Institute & School of Pharmaceutical Sciences, Taizhou University, Taizhou, Zhejiang 318000, P. R. China;
    bLinhai Branch of Taizhou Ecological Environment Bureau, Linhai, Taizhou, Zhejiang, 317000, P. R. China
*E-mail: leiwang88@hotmail.com; yongmin.ma@tzc.edu.cn.

Received date: 2026-02-06

  Revised date: 2026-03-30

  Online published: 2026-05-14

Supported by

National Natural Science Foundation of China (No. 22471187)

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Abstract

Herein, we present a highly efficient photoinduced radical addition/defluoroalkylation of dihydroquinazolinones and CF3-substituted alkenes, affording a diverse set of gem-difluoroalkenes under mild visible-light conditions. This strategy relies on C-C bond cleavage of dihydroquinazolinones to generate alkyl radicals, followed by addition and β-fluoride elimination. This reaction exhibits broad substrate scope, excellent functional group tolerance, and operational simplicity.

Key words： gem-Difluoroalkenes; C-F bond cleavage; Photochemistry; α-Trifluoromethyl alkenes

Cite this article

Wang Bin , Ye Bo , Wang Lei , He Hong , Ma Yongmin . Photoinduced C-F Bond Cleavage α-Trifluoromethyl Alkenes for the Synthesis of gem-Difluoroalkenes[J]. Chinese Journal of Organic Chemistry, 0 : 260514 . DOI: 10.6023/cjoc202512002

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