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Chinese Journal of Organic Chemistry >

0 202603003 - 202603003

DOI: https://doi.org/10.6023/cjoc202603003

ARTICLE

UV-Light-Driven Construction of Quinazolinones from Aryl Aldehydes and Anthranilamides

  • Feng Yadong ,
  • Bi Siheng ,
  • Tang Mingqing ,
  • Wu Yangjie ,
  • Pi Chao
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  • aHenan Key Laboratory of Chemical Biology and Organic Chemistry, Key Laboratory of Applied Chemistry of Henan Universities, Pingyuan Laboratory, State Key Laboratory of Coking Coal Resources Green Exploitation and College of Chemistry, Zhengzhou University, Zhengzhou 450052;
    bEngineering Research Center of Natural Cosmeceuticals College of Fujian Province, Department of Public Health and Medical Technology, Xiamen Medical College, Xiamen 361023;
    cEngineering Research Centre of Molecular Medicine of Ministry of Education, Key Laboratory of Fujian Molecular Medicine, Key Laboratory of Precision Medicine and Molecular Diagnosis of Fujian Universities, Key Laboratory of Xiamen Marine and Gene Drugs, School of Biomedical Sciences, Huaqiao University, Xiamen 361021

Received date: 2026-03-03

  Revised date: 2026-04-24

  Online published: 2026-05-27

Supported by

Natural Science Foundation of Henan (No. 252300423136),Natural Science Foundation of Fujian Province,China (No. 2025J011469), and the Natural Science Foundation of Xiamen, China (No. 3502Z202372064)

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Abstract

Herein, we report a UV-light-driven strategy for the construction of quinazolinone frameworks under photocatalyst-free conditions. Readily available and inexpensive tert-butyl hydroperoxide (TBHP) serves as a radical initiator to promote a radical-involved coupling/cyclization cascade between o-aminobenzamides and aryl aldehydes under UV irradiation, affording a range of quinazolinone derivatives efficiently. This protocol features operational simplicity, high feedstock accessibility, and good conversion efficiency, while avoiding the use of transition metals and external photocatalysts. As such, it provides a valuable complementary approach to the green and sustainable synthesis of quinazolinone scaffolds, an important class of pharmaceutical relevant scaffolds.

Key words： UV-light; photocatalyst-free; quinazolinones

Cite this article

Feng Yadong , Bi Siheng , Tang Mingqing , Wu Yangjie , Pi Chao . UV-Light-Driven Construction of Quinazolinones from Aryl Aldehydes and Anthranilamides[J]. Chinese Journal of Organic Chemistry, 0 : 202603003 -202603003 . DOI: 10.6023/cjoc202603003

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