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0 3009

DOI: https://doi.org/10.6023/cjoc202603009

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Advances in Visible-Light Induced Trifluoromethylation with Trifluoroacetic Acid and Its Anhydride as Inexpensive and Effective Trifluoromethylation Reagents

  • Bin Huang ,
  • Zhantu Xu ,
  • Jing Chen ,
  • Weiping Su ,
  • Chen Zhu
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  • aCollege of Chemistry, Fuzhou University, Fuzhou, Fujian 350108
    bState Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350108
    cFrontiers Science Center for Transformative Molecules, Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, Shanghai Jiao Tong University, Shanghai 200240

Received date: 2026-03-06

  Revised date: 2026-05-09

  Online published: 2026-06-18

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Abstract

The trifluoromethyl group plays a crucial role in pharmaceuticals, agrochemicals, and materials science, driving extensive efforts in the discoveries of new trifluoromethylating reagents and the development of methods for introducing this group into molecular frameworks. Over the past decade, the field of visible-light photocatalysis has flourished. Visible-light photocatalytic trifluoromethylation, as a green and efficient synthetic strategy, has emerged as an important method for constructing trifluoromethyl-containing molecules with broad application prospects. This article systematically reviews the research progress of exploring on trifluoroacetic acid and its anhydride as inexpensive and effective trifluoromethyl reagents for visible-light catalyzed trifluoromethylation reactions. It focuses on key scientific issues such as activating methods, reaction mechanisms, and transformations. The insights gained are expected to facilitate the rational design of effective photocatalytic strategies for future utilization of trifluoroacetic acid or its anhydride.

Key words： trifluoromethylation; trifluoroacetic acid and its anhydride; visible-light photocatalysis; LMCT

Cite this article

Bin Huang , Zhantu Xu , Jing Chen , Weiping Su , Chen Zhu . Advances in Visible-Light Induced Trifluoromethylation with Trifluoroacetic Acid and Its Anhydride as Inexpensive and Effective Trifluoromethylation Reagents[J]. Chinese Journal of Organic Chemistry, 0 : 3009 . DOI: 10.6023/cjoc202603009

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