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DOI: https://doi.org/10.6023/cjoc202604034

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Research Progress on Electro-Driven Sulfur Chemistry Synthesis

  • Zhang Xiangjin ,
  • Jiang Xuefeng
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  • Hainan Institute of East China Normal University, sanya 572025

Received date: 2026-04-23

  Revised date: 2026-05-13

  Online published: 2026-06-26

Supported by

Project supported by the National Natural Science Foundation of China (No. 22125103).

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Abstract

Organic sulfur compounds are widely used in medicinal chemistry, asymmetric catalysis, and functional materials. The unique multivalent redox properties of sulfur atoms (-2, 0, +2, +4, +6) make their synthesis highly dependent on precise redox regulation. Traditional methods rely on hazardous oxidants such as peroxides and hypervalent iodine, suffering from low atom economy, over-oxidation, and byproduct contamination. Electrocatalysis employs electrons as green redox reagents, enabling stepwise and controllable transformation of sulfur valence states by precisely regulating electron transfer rates and pathways through potential, current, electrodes, and media, offering a green, safe, highly selective, and atom-economical approach. This article focuses on the electrocatalytic green redox catalysis mode, systematically sorts out various synthetic strategies of electro-driven sulfur chemistry, summarizes the related research progress, and deeply analyzes its reaction mechanism.

Key words： Sulfur Chemistry; Electrochemistry; Electroredox

Cite this article

Zhang Xiangjin , Jiang Xuefeng . Research Progress on Electro-Driven Sulfur Chemistry Synthesis[J]. Chinese Journal of Organic Chemistry, 0 : 0 . DOI: 10.6023/cjoc202604034

References

[1] (a) Wang, M.; Jiang, X. Top. Curr. Chem. 2018, 376, 14. (b) Huang, S.; Wang, M.; Jiang, X. Chem. Soc. Rev. 2022, 51, 8351-8377. (c) Narayan, M.; Welker, E.; Wedemeyer, W. J.; Scheraga, H. D. Acc. Chem. Res. 2000, 33, 805–812. (d) Lee, M. H.; Yang, Z.; Lim, C. W.; Lee, Y. H.; Dongbang, S.; Kang, C.; Kim, J. S. Chem. Rev. 2013, 113, 5071–5109. (e) Zuo, S.; Liu, T.; Li, L.; Xu, H.; Guo, J.; Wang, Q.; Yang, Y.; He, Z.; Sun, J.; Sun, B. Cell Rep. Med. 2024, 5, 101432. (f) Jiang, C.-S.; Müller, W. E. G.; Schröder, H. C.; Guo, Y.-W. Chem. Rev. 2011, 112, 2179-2207.
[2] (a) Chalker, J. M.; Worthington, M. J. H.; Lundquist, N. A.; Esdaile, L. J. Top. Curr. Chem. 2019, 377, 14. (b) Meng, J.; Jiang, X. Sci. Sin. Chim. 2025, 55, 1113 (in Chinese). (孟娇龙, 姜雪峰, 中国科学: 化学, 2025, 55, 1113.). (c) Mazumder, K.; Voit, B.; Banerjee, S. ACS Omega 2024, 9, 6253-6279.
[3] (a) Song, H.; Meng, J.; Jiang, X. Natl. Sci. Rev. 2025, 12, nwaf475. (b) Ye, H.; Li, M.; Liu, T.; Li, Y.; Lu, J. ACS Energy Letters 2020, 5, 2234-2245. (c) Yoshida, J.; Kataoka, K.; Horcajada, R.; Nagaki, A. Chem. Rev. 2008, 108, 2265–2299.
[4] Block, E.; Bayer, T.; Naganathan, S.; Zhao, S.-H. J. Am. Chem. Soc. 1996, 118, 2799–2810.
[5] Yoshida, J.; Kataoka, K.; Horcajada, R.; Nagaki, A. Chem. Rev. 2008, 108, 2265–2299.
[6] (a) Amri, N.; Wirth, T. Chem. Rec. 2021, 21, 2526-2537. (b) Lei, Z.-L.; Tang, H.-T.; Pan, Y.-M. Green Chem. 2025, 27, 15442-15461.
[7] Yang, Z.; Shi, W.; Alhumade, H.; Yi, H.; Lei, A. Nat. Synth. 2023, 2, 217-230.
[8] Sushma, C.; Pramanik, R.; Barathkumar, J.; Nagarajan, S. Asian J. Org. Chem. 2025, 14, e00388.
[9] Wang, M.; Jiang, X. ACS Sustainable Chem. Eng. 2022, 10, 671-677.
[10] (a) Ye, Z.; Zhang, X.; Ma, W.; Zhang, F. Green Chem. 2023, 25, 2524-2540. (b) Huang, J.; Li, X.; Xu, L.; Wei, Y. Org. Chem. Front. 2025, 12, 3454-3461. (c) Wang, S.; Zhi, S.; Cai, T.; Li, D.; Xu, B.; Yang, Y.; Hu, Y.; Zhang, J.; Qiao, Z.; Yuan, M.; Jin, Y. J. Org. Chem. 2025, 90, 17952-17965. (d) Song, X.; Yang, Z.; Yin, W.; Li, X.; Qian, L.; Jin, Y.; Yang, M. J. Org. Chem. 2025, 90, 13253-13261. (e) Li, L.; Li, Y.; Hu, J.; Yang, C.; Sun, J.; Qian, P. J. Org. Chem. 2025, 90, 15313-15323. (f) Wu, M.; Chen, M.; Wang, W.; Liu, P.; Sun, P. J. Org. Chem. 2025, 90, 7351-7358.
[11] Laudadio, G.; Straathof, N. J. W.; Lanting, M. D.; Knoops, B.; Hessel, V.; Noël, T. Green Chem. 2017, 19, 4061-4066.
[12] Park, J. K.; Lee, S. J. Org. Chem. 2021, 86, 13790-13799.
[13] Yang, Z.; Shi, Y.; Zhan, Z.; Zhang, H.; Xing, H.; Lu, R.; Zhang, Y.; Guan, M.; Wu, Y. ChemElectroChem 2018, 5, 3619-3623.
[14] Zhang, X.; Cui, T.; Zhang, Y.; Gu, W.; Liu, P.; Sun, P. Adv. Synth. Catal. 2019, 361, 2014-2019.
[15] Laudadio, G.; Barmpoutsis, E.; Schotten, C.; Struik, L.; Govaerts, S.; Browne, D. L.; Noël, T. J. Am. Chem. Soc. 2019, 141, 5664-5668.
[16] Wang, H.; Yu, M.; Zhang, P.; Wan, H.; Cong, H.; Lei, A. Sci. Bull. 2022, 67, 79-84.
[17] Zhou, P.; Niu, K.; Song, H.; Liu, Y.; Wang, Q. Green Chem. 2022, 24, 5760-5763.
[18] Klein, M.; Waldvogel, S. R. Angew. Chem. Int. Ed. 2021, 60, 23197-23201.
[19] Kong, X.; Lin, L.; Chen, X.; Chen, Y.; Wang, W.; Xu, B. ChemSusChem 2021, 14, 3277-3282.
[20] Li, X.; Huang, J.; Xu, L.; Liu, J.; Wei, Y. Adv. Synth. Catal. 2023, 365, 4647-4653.
[21] Li, Y.; Wen, L.; Guo, W. Chem. Soc. Rev. 2023, 52, 1168-1188.
[22] Bilal, M.; Liu, X.-B.; Liang, Y.-F. Tetrahedron Chem 2025, 15, 100141.
[23] Jang, H.-Y. Org. Biomol. Chem. 2021, 19, 8656-8686.
[24] Mulina, O. M.; Ilovaisky, A. I.; Terent'ev, A. O. Eur. J. Org. Chem. 2018, 2018, 4648-4672.
[25] Hu, X.; Zhong, K.; Ruan, Z. Chem. Commun. 2024, 60, 8573-8576.
[26] Kuzmin, J.; Röckl, J.; Schwarz, N.; Djossou, J.; Ahumada, G.; Ahlquist, M.; Lundberg, H. Angew. Chem. Int. Ed. 2023, 62, e202304272.
[27] Pople, J. M. M.; Nicholls, T. P.; Pham, L. N.; Bloch, W. M.; Lisboa, L. S.; Perkins, M. V.; Gibson, C. T.; Coote, M. L.; Jia, Z.; Chalker, J. M. J. Am. Chem. Soc. 2023, 145, 11798-11810.
[28] Krumbiegel, C.; Breitschaft, F. A.; Waldvogel, S. R. Chem. Commun. 2025, 61, 11267-11270.
[29] Sun, F.; Liu, X.; Chen, X.; Qian, C.; Ge, X. Chin. J. Org. Chem. 2017, 37, 2211-2220 (in Chinese). (孙丰莉, 刘学民, 陈新志, 钱超, 葛新, 有机化学, 2017, 37, 2211-2220.)
[30] Bu, F.; Deng, Y.; Shi, P.; Huang, R.; Tan, J.; Li, H.; Chen, Y.; Lei, A.; Li, W. J. Am. Chem. Soc. 2026, 148, 7322-7332.
[31] Strehl, J.; Hilt, G. Eur. J. Org. Chem. 2021, 2022, 35-39.
[32] Ang, N. W. J.; Ackermann, L. Chem. Eur. J. 2021, 27, 4883-4887.
[33] Kong, Z.; Pan, C.; Li, M.; Wen, L.; Guo, W. Green Chem. 2021, 23, 2773-2777.
[34] Lou, T. S. B.; Kawamata, Y.; Ewing, T.; Correa-Otero, G. A.; Collins, M. R.; Baran, P. S. Angew. Chem. Int. Ed. 2022, 61, e202208080.
[35] Xu, Z.; Zhou, Z.; Wang, X.; Yang, Y.; Pan, Y.; Wang, Y. Green Chem. 2026, 28, 120-131.
[36] (a) Xiao, X.; Feng, M.; Jiang, X. Angew. Chem. Int. Ed. 2016, 55, 14121–14125. (a) Xiao, X.; Xue, J.; Jiang, X. Nat. Commun. 2018, 9, 2191–2200. (a) Xue, J.; Jiang, X. Nat. Commun. 2020, 11, 2191–2199. (a) Yu, Q.; Zhang, X.; Jiang, X. Angew. Chem. Int. Ed. 2024, e202408158. (a) Huang, S.; Zeng, D., Wang. M.; Jiang, X. Nat. Synth. 2026, 5, 398-408.
[37] Zhang, X.; Bai, L.; Li, C.; Bai, L.; Jiang, X. J. Am. Chem. Soc. 2026, 148, 12793-12804.
[38] Wang, Z.; Ma, C.; Fang, P.; Xu, H.; Mei, T. Acta Chim. Sinica 2022, 80, 1115-1134 (in Chinese). (王振华, 马聪, 方萍, 徐海超, 梅天胜, 化学学报, 2022, 80, 1115-1134.)
[39] Francke, R.; Little, R. D. Chem. Soc. Rev. 2014, 43, 2492–2521.
[40] Bai, L.; Jiang, X. CCS Chem. 2025, 7, 1889–1902.
[41] Huang, P.; Wang, P.; Tang, S., Fu, Z.; Lei, A. Angew. Chem. Int. Ed. 2018, 57, 8115–8119.
[42] Liu, D.; Ma, H. X.; Fang, P.; Mei, T. S. Angew. Chem. Int. Ed. 2019, 58, 5033-5037.
[43] Kang, J.-C.; Li, Z.-H.; Chen, C.; Dong, L.-K.; Zhang, S.-Y. J. Org. Chem. 2021, 86, 15326-15334.
[44] Wang, D.-Y.; Si, Y.; Guo, W.; Fu, Y. Nat. Commun. 2021, 12, 3220.
[45] Fährmann, J.; Hilt, G. Chem. Eur. J. 2021, 27, 11141-11149.
[46] Li, Y.; Wang, H.; Wang, Z.; Alhumade, H.; Huang, Z.; Lei, A. Chem. Sci. 2023, 14, 372-378.
[47] Fu, M.-Q.-H.; He, Y.-H.; Guan, Z. Org. Chem. Front. 2024, 11, 6790-6796.
[48] Chen, H.; Yin, Y.; Wang, G.; Xiao, X.; Jiang, X.; Feng, M. Angew. Chem. Int. Ed. 2025, 64, e202512612.
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