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Chinese Journal of Organic Chemistry >

0 4046

DOI: https://doi.org/10.6023/cjoc202604046

Frustrated Ion-Pair Catalyzed Efficient Deprotection of Acetals and Ketals

  • Chao Yang ,
  • Ruoqi Li ,
  • Yu Zhang ,
  • Ming Zou ,
  • Peng Chen ,
  • Zhenhua Jia
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  • aCollege of Advanced Interdisciplinary Science and Technology, Henan University of Technology, Zhengzhou, 450001;
    bDepartment of Chemistry, Fudan University, Shanghai, 200433

Received date: 2026-04-28

  Revised date: 2026-05-21

  Online published: 2026-07-06

Supported by

National Natural Science Foundation of China (No.22401080) and the Start-up Grant of Henan University of Technology (No.2023BS006).

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Abstract

Acetals and ketals are among the most important protecting groups for carbonyl groups and are widely used in synthetic chemistry. In this work, we presented an efficient deprotection reaction for cyclic acetals and ketals catalyzed by triaryl carbenium ion-pair. Under mild and metal-free conditions within only 20 minutes, a wide range of carbonyl products were obtained in high yields (up to 98%) with excellent functional group tolerance, including aldehydes, ketones and natural products. Moreover, this deprotection process was practical for gram-scale synthesis, featuring simple operation and practical application.

Key words： Metal-free catalysis; Frustrated ion-pair; Deprotection of acetals and ketals

Cite this article

Chao Yang , Ruoqi Li , Yu Zhang , Ming Zou , Peng Chen , Zhenhua Jia . Frustrated Ion-Pair Catalyzed Efficient Deprotection of Acetals and Ketals[J]. Chinese Journal of Organic Chemistry, 0 : 4046 . DOI: 10.6023/cjoc202604046

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