A novel phenothiazine-based ratiometric fluorescent probe was rationally designed and synthesized for the selective detection and imaging of sulfur dioxide derivatives (HSO3-/SO32-). HSO3-/SO32- induces aggregation-state modulation of probe T2, which causes a significant blue shift in its fluorescence emission maximum. Spectroscopic studies demonstrated that T2 exhibits high selectivity and sensitivity toward HSO3-/SO32-, with a detection limit as low as 3.96 μM. Notably, T2 was successfully applied to the fluorescence imaging of exogenous HSO3-/SO32- in living cells and plant tissues. In addition, T2-based test strips were developed for the rapid and visual detection of HSO3-/SO32- in aqueous media. These results indicate that T2 represents a promising analytical tool for the detection and bioimaging of SO2 derivatives in environmental and biological systems.
Xiao Zhongshan
,
Wang Han
,
Xu Lu
,
He Ruijuan
,
Yang Guojing
,
Wang Yakun
,
Liu Zhaomin
,
Zhang Tao
. A Novel Phosphate-Ester-Phenothiazine Fluorescent Probe for Detection and Imaging of Sulfur Dioxide Derivatives[J]. Chinese Journal of Organic Chemistry, 0
: 202603043
-202603043
.
DOI: 10.6023/cjoc202603043
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