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0 202603027

DOI: https://doi.org/10.6023/cjoc202603027

Synthesis and application of 3-aryl substituted indenyl phosphines in Suzuki-Miyaura cross-coupling reactions at low catalyst loadings

  • Qiong Chen ,
  • Xinyu Chen ,
  • Youli Guo ,
  • Sixuan Meng ,
  • Jian Chen ,
  • Jia Yuan ,
  • Guang-Ao Yu
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  • aState Key Laboratory of New Textile Materials and Advanced Processing, Wuhan Textile University, Wuhan 430200;
    bNational Key Laboratory of Green Pesticide, College of Chemistry, Central China Normal University, Wuhan 430079, P.R. China

Received date: 2026-03-19

  Revised date: 2026-05-26

  Online published: 2026-07-24

Supported by

Natural Science Foundation of China (No. 22371084, 21072071, 21472060 and 21772058), the 111 Project B17019, self-determined research funds of CCNU from the colleges’ basic research and operation of MOE (No. CCNU17CG0011, CCNU17KYZHSY07, and CCNU18KYZHSY06).

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Abstract

This study describes a new class of 3-substituted indenyl phosphine ligands L1-L4, which can improve the efficiency of the synthesis of the key pesticide intermediates 1 and 2 by Palladium-catalyzed Suzuki-Miyaura cross-coupling reactions. It is noted that the catalyst loading of Pd(OAc)2 down to 0.02 mol% can be achieved.

Key words： Indenyl; Phosphine ligand; Suzuki-Miyaura cross-coupling reactions; Pesticide intermediates

Cite this article

Qiong Chen , Xinyu Chen , Youli Guo , Sixuan Meng , Jian Chen , Jia Yuan , Guang-Ao Yu . Synthesis and application of 3-aryl substituted indenyl phosphines in Suzuki-Miyaura cross-coupling reactions at low catalyst loadings[J]. Chinese Journal of Organic Chemistry, 0 : 202603027 . DOI: 10.6023/cjoc202603027

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