A new andrastin-type meroterpenoids derivative, atlantinone C (1) and four known analogues, including bialorastin C (2),peniciterpenolide A (3),peniandrastin G (4),10-formyl andrastone A (5) were isolated from an endophytic fungus Penicillium sp. L02 in this study. Their structures were elucidated by detailed analysis of comprehensive spectroscopic data, and the structure of 1 was further determined by X-ray diffraction analysis. In vitro anti-inflammatory assays revealed that compounds 4 and 5 exhibited significant inhibitory activities against NO production in LPS-induced RAW 264.7 cells, with IC50 values of 29.09 ± 1.33 μM and 26.71 ± 1.40 μM, respectively, which were more potent than the positive control indomethacin (36.69 ± 1.23 μM). In vitro antibacterial evaluation against four common clinical drug-resistant bacteria indicated that the MIC of compounds (1-5) were greater than 64.0 μg/mL, showing no clinically significant antibacterial activity.
Liu Li
,
Bi Xiaobin
,
Guan Xinlei
,
Wu Tao
,
Guo Zhilei
,
Song Hongping
,
Zhu Xiaoqiang
,
Lei Liang
. Study on Secondary Metabolites and their Biological Activities from an Endophytic Fungus Penicillium sp. L02 of Ainsliaea fragrans[J]. Chinese Journal of Organic Chemistry, 0
: 202603045
.
DOI: 10.6023/cjoc202603045
[1] Awakawa T.; Mori T.; Ushimaru R.; Nat. Prod. Rep.2023, 40, 46.
[2] Day A. J.; George J. H.; J. Nat. Prod.2020, 83, 2305.
[3] Kurosawa N.; Ishikawa Y.; Katagiri T.; J. Nat. Med.2026, 80, 91.
[4] Qin Y. Y.; Liu X. B.; Xiong T. T.; Fitoterapia.2025, 183, 106494.
[5] Zhao M.; Tang Y.; Xie J.; Eur. J. Med. Chem.2021, 209, 112860.
[6] Barra L.; Abe, I. Nat. Prod. Rep.2021, 38, 566.Gao, Z.-Y.; Lu, X.-N.; Li, Y.-N.; Chin. J. Org. Chem. 2025, 45, 814 (in Chinese).
(高志宇, 路雪娜, 李奕晴, 有机化学, 2025, 45, 814).
[8] Zhang Z.; Wang Z.; Cui Y.; J. Ethnopharmacol.2026, 359, 121117.
[9] Wu L.; Yang Y.; Lin M.; Phytomedicine.2024, 123, 155213.
[10] Lai M.; Cui Y.; Yang Y.; Fitoterapia.2025, 184, 106579.
[11] Zhang R.; Tang C.; Liu H. C.; Org. Lett.2019, 21, 8211-8214.
[12] Lei L.; Xue Y. B.; Liu Z.; Sci. Rep.2015, 5, 13544.Chen, X.-Y.; Bi, X.-B.; Liu, Y.; J. Chin. Med. Mater. 2021, 44, 607 (in Chinese).
(陈欣悦, 毕晓宾, 刘阳, 中药材, 2021, 44, 607).
[14] Wang X.; Sena Filho J. G.; Hoover A. R.; J. Nat. Prod.2010, 73, 942.
[15] Yan L. H.; Li P. H.; Li X. M.; Bioorg. Chem.2024, 143, 107073.
[16] Jia F. F.; Zhang M. L.; Fan J. P.; Org. Chem. Front.2023, 10, 4598.
[17] Chang J.; Ouyang Q. X.; Peng X. G.; Bioorg. Chem.2023, 139, 106745.
[18] Qin Y. Y.; Huang X. S.; Liu X. B.; Nat. Prod. Res.2022, 36, 3262.
[19] Hu, S.; Zhao, L.-L.; Li, X.-Y.; Chin. J. Org. Chem. 2026, 46, 300 (in Chinese).
(胡苏, 赵丽莲, 李昕宇, 有机化学, 2026, 46, 300).
[20] Zhang, Y.; Xu, X.-F.; Yan, H.; Chin. J. Org. Chem. 2025, 45, 2620 (in Chinese).
(张玉, 徐雪峰, 闫浩, 有机化学, 2025, 45, 2620).
[21] Huang Z.-D.; Wang W.-J.; Liao, L.-X. Chin. J. Antibiot.2023, 48, 1126. (in Chinese).
(黄泽雕, 王文静, 廖梁秀, 中国抗生素杂志, 2023, 48, 1126.)
