A visible-light-induced radical trifluoromethylation/cyclization reaction of N-isopentenyl/N-4-methyl-3-penten-1-yl-indoles or N-isopentenyl/ N-4-methyl-3-penten-1-yl-benzimidazoles is reported using with CF₃Br as cost-effective and readily available trifluoromethylating reagent. This method enables the efficient construction of trifluoromethyl-substituted indole/benzimidazole-fused pyrrolidine or piperidine derivatives under mild conditions. The protocol exhibits the advantages of high functional group compatibility, a broad substrate scope, and the use of visible light as a green energy source.
Pan Xiaona
,
Wen Huan
,
Wang Ke-Hu
,
Wang Junjiao
,
Huang Danfeng
,
Hu Yulai
. Synthesis of Trifluoromethylated Indole/Benzimidazole-Fused Pyrrolidines or Piperidines via Visible-Light-Driven Radical Trifluoromethylation/Cyclization[J]. Chinese Journal of Organic Chemistry, 0
: 202604033
.
DOI: 10.6023/cjoc202604033
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(马然松,邓周斌,王克虎,黄丹凤,胡雨来,吕肖波,有机化学,2022,43,353)
