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Chinese Journal of Organic Chemistry >

0 202604016

DOI: https://doi.org/10.6023/cjoc202604016

ARTICLE

Copper-Catalyzed Ring-Opening Fluorosulfonylation of Unstrained cyclic Alkylsilyl Peroxides

  • Ma Yuxue ,
  • Pei Niping ,
  • Li Yanhui ,
  • Li Wei ,
  • Wang Lijing
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  • aCollege of Chemistry and Materials Science, Hebei University, Baoding City, 071002;
    bKey Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Key Laboratory of Chemical Biology of Hebei Province, Baoding, 071002

Received date: 2026-04-08

  Revised date: 2026-05-20

  Online published: 2026-08-17

Supported by

Natural Science Foundation of Hebei Province (No. B2025201101), the Hebei Province Innovation Capability Enhancement Plan Project (No. 22567632H), and the Hebei University Laboratory Open Project (No. sy202533) for financial support.

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Abstract

Sulfonyl fluorides (R‑SO2F) have emerged as versatile building blocks in organic synthesis, medicinal chemistry, and materials science, owing to their excellent stability and unique reactivity. Herein, we report a concise copper-catalyzed protocol for the synthesis of carbonyl-containing aliphatic sulfonyl fluorides from unstrained cycloalkyl silyl peroxides, involving sequential ring-opening, SO₂ insertion, and fluorination of alkyl radicals. This approach features mild conditions, operational simplicity, and broad substrate scope, tolerating various cyclic skeletons and functional groups. Furthermore, the products readily undergo diverse downstream SuFEx derivatizations, providing a new strategy for the assembly of structurally diverse alkyl sulfonyl fluorides.

Key words： copper catalysis; sulfonyl fluoride; unstrained ring opening; sulfur dioxide insertion; SuFEx reaction

Cite this article

Ma Yuxue , Pei Niping , Li Yanhui , Li Wei , Wang Lijing . Copper-Catalyzed Ring-Opening Fluorosulfonylation of Unstrained cyclic Alkylsilyl Peroxides[J]. Chinese Journal of Organic Chemistry, 0 : 202604016 . DOI: 10.6023/cjoc202604016

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